Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P19971
UPID:
TYPH_HUMAN
Alternative names:
Gliostatin; Platelet-derived endothelial cell growth factor; TdRPase
Alternative UPACC:
P19971; A8MW15; H9KVA0; Q13390; Q8WVB7
Background:
Thymidine phosphorylase, also known as Gliostatin or Platelet-derived endothelial cell growth factor, plays a pivotal role in maintaining blood vessel integrity, promoting endothelial cell growth, and exhibiting angiogenic and chemotactic activities. It catalyzes the reversible phosphorolysis of thymidine, facilitating the utilization of produced molecules for energy or nucleotide synthesis.
Therapeutic significance:
Linked to Mitochondrial DNA depletion syndrome 1, MNGIE type, Thymidine phosphorylase's dysfunction underscores its critical biological role. Targeting its pathway offers a promising avenue for therapeutic intervention in mitochondrial-related diseases.