Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P20472
UPID:
PRVA_HUMAN
Alternative names:
-
Alternative UPACC:
P20472; B2R4H7; P78378; Q4VB78; Q5R3Q9
Background:
Parvalbumin alpha, a protein encoded by the gene with accession number P20472, plays a crucial role in muscle function. It is primarily involved in the relaxation phase following muscle contraction by binding to two calcium ions. This action is vital for the smooth transition between contraction and relaxation in muscle fibers.
Therapeutic significance:
Understanding the role of Parvalbumin alpha could open doors to potential therapeutic strategies. Its pivotal function in muscle relaxation highlights its importance in muscle physiology and suggests that further exploration could reveal novel approaches to treating muscle-related disorders.