Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P20849
UPID:
CO9A1_HUMAN
Alternative names:
-
Alternative UPACC:
P20849; Q13699; Q13700; Q5TF52; Q6P467; Q96BM8; Q99225; Q9H151; Q9H152; Q9Y6P2; Q9Y6P3
Background:
Collagen alpha-1(IX) chain is a structural component of hyaline cartilage and the vitreous of the eye, playing a crucial role in maintaining the integrity and function of these tissues. This protein's unique composition and localization underscore its importance in skeletal and ocular health.
Therapeutic significance:
Mutations in the gene encoding Collagen alpha-1(IX) chain are linked to Multiple epiphyseal dysplasia 6 and Stickler syndrome 4, conditions marked by skeletal dysplasia and ocular disorders. Understanding the role of Collagen alpha-1(IX) chain could open doors to potential therapeutic strategies for these debilitating diseases.