Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P21860
UPID:
ERBB3_HUMAN
Alternative names:
Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3
Alternative UPACC:
P21860; A8K6L6; B4DIK7; B4DV32; E9PDT8; Q9BUD7
Background:
Receptor tyrosine-protein kinase erbB-3, also known as Proto-oncogene-like protein c-ErbB-3 and Tyrosine kinase-type cell surface receptor HER3, plays a pivotal role in cell communication and signal transduction. Activated by neuregulins, particularly neuregulin-1 (NRG1), it engages in phosphorylation processes that are crucial for cell differentiation and proliferation.
Therapeutic significance:
The protein's involvement in diseases such as Lethal congenital contracture syndrome 2, Erythroleukemia, familial, and Visceral neuropathy, familial, 1, underscores its potential as a target for therapeutic intervention. Understanding the role of Receptor tyrosine-protein kinase erbB-3 could open doors to potential therapeutic strategies.