Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
It includes extensive molecular simulations of the receptor in its native membrane environment and the ensemble virtual screening accounting for its conformational mobility. In the case of dimeric or oligomeric receptors, the whole functional complex is modelled, and the tentative binding pockets are determined on and between the subunits to cover the whole spectrum of possible mechanisms of action.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P22888
UPID:
LSHR_HUMAN
Alternative names:
Luteinizing hormone receptor
Alternative UPACC:
P22888; Q14751; Q15996; Q9UEW9
Background:
The Lutropin-choriogonadotropic hormone receptor, a pivotal protein in human physiology, serves as the receptor for lutropin-choriogonadotropic hormone. This receptor's activity, crucial for reproductive function, is mediated by G proteins that activate adenylate cyclase, as detailed in scientific literature (PubMed:11847099).
Therapeutic significance:
Linked to Familial male precocious puberty and Luteinizing hormone resistance, this receptor's aberrations manifest in significant reproductive disorders. Understanding its role could unveil new therapeutic strategies for these conditions, highlighting its importance in medical research.