Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P23434
UPID:
GCSH_HUMAN
Alternative names:
Lipoic acid-containing protein
Alternative UPACC:
P23434; Q9H1E9
Background:
The Glycine cleavage system H protein, mitochondrial, also known as Lipoic acid-containing protein, plays a crucial role in the degradation of glycine. It facilitates the transfer of the methylamine group of glycine, ensuring efficient energy production and metabolic function.
Therapeutic significance:
Non-ketotic hyperglycinemia, a severe neurological disorder, is directly linked to mutations in the gene encoding this protein. Understanding its mechanism opens avenues for targeted therapies, potentially revolutionizing treatment for affected individuals.