Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P23443
UPID:
KS6B1_HUMAN
Alternative names:
70 kDa ribosomal protein S6 kinase 1; Ribosomal protein S6 kinase I; Serine/threonine-protein kinase 14A; p70 ribosomal S6 kinase alpha
Alternative UPACC:
P23443; B2R779; B4DLT4; B4DTG1; E7ESB8; F6UYM1; Q7Z721
Background:
Ribosomal protein S6 kinase beta-1, also known as 70 kDa ribosomal protein S6 kinase 1, plays a crucial role in cell proliferation, growth, and cycle progression. It acts downstream of mTOR signaling, responding to growth factors and nutrients by regulating protein synthesis and cell survival. This kinase phosphorylates several key proteins involved in the translation initiation and elongation processes, contributing to the dynamic control of protein synthesis.
Therapeutic significance:
Understanding the role of Ribosomal protein S6 kinase beta-1 could open doors to potential therapeutic strategies.