Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P26232
UPID:
CTNA2_HUMAN
Alternative names:
Alpha N-catenin; Alpha-catenin-related protein
Alternative UPACC:
P26232; B3KXE5; B7Z2W7; B7Z352; B7Z898; Q4ZFW1; Q53R26; Q53R33; Q53T67; Q53T71; Q53TM8; Q7Z3L1; Q7Z3Y0
Background:
Catenin alpha-2, also known as Alpha N-catenin and Alpha-catenin-related protein, plays a pivotal role in the nervous system's cell-cell adhesion and differentiation. It is essential for cortical neuronal migration and neurite growth, acting as a negative regulator of the Arp2/3 complex and actin polymerization. This regulation is crucial for maintaining neurite growth and stability by suppressing excessive actin branching. Additionally, Catenin alpha-2 is involved in synaptic morphological plasticity and the lamination of the cerebellar and hippocampal regions during development.
Therapeutic significance:
Catenin alpha-2's mutation is linked to Cortical dysplasia, complex, with other brain malformations 9, a severe neurodevelopmental disorder. Understanding the role of Catenin alpha-2 could open doors to potential therapeutic strategies for this and related neurological conditions.