Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P27037
UPID:
AVR2A_HUMAN
Alternative names:
Activin receptor type IIA
Alternative UPACC:
P27037; B2RAB8; B4DWQ2; D3DP85; Q53TH4; Q6NWV2; Q92474
Background:
Activin receptor type-2A, a transmembrane serine/threonine kinase, is pivotal in cellular communication. It forms a receptor complex upon ligand binding, involving two type II and two type I kinases. This complex initiates a cascade, phosphorylating type I receptors, which then autophosphorylate and activate SMAD transcriptional regulators. It is the receptor for activin A, activin B, and inhibin A, playing a crucial role in adipogenesis mediated by GDF6.
Therapeutic significance:
Understanding the role of Activin receptor type-2A could open doors to potential therapeutic strategies. Its involvement in critical signaling pathways underscores its potential as a target in regulating adipogenesis and cellular communication.