Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P27694
UPID:
RFA1_HUMAN
Alternative names:
Replication factor A protein 1; Single-stranded DNA-binding protein
Alternative UPACC:
P27694; A8K0Y9; Q59ES9
Background:
Replication protein A 70 kDa DNA-binding subunit, also known as Replication factor A protein 1, plays a crucial role in DNA replication and repair. It stabilizes single-stranded DNA intermediates, recruits proteins for DNA metabolism, and is pivotal in DNA damage response, including nucleotide excision repair and telomere maintenance.
Therapeutic significance:
Given its essential role in telomere maintenance and response to DNA damage, understanding Replication protein A could lead to breakthroughs in treating Pulmonary fibrosis and bone marrow failure, telomere-related diseases, by targeting the underlying genetic variants.