Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
This process includes extensive molecular simulations of the receptor in its native membrane environment, along with ensemble virtual screening that accounts for its conformational mobility. In the case of dimeric or oligomeric receptors, the entire functional complex is modelled, identifying potential binding pockets on and between the subunits to encompass all possible mechanisms of action.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P28335
UPID:
5HT2C_HUMAN
Alternative names:
5-hydroxytryptamine receptor 1C; Serotonin receptor 2C
Alternative UPACC:
P28335; B1AMW4; Q5VUF8; Q9NP28
Background:
The 5-hydroxytryptamine receptor 2C, also known as the serotonin receptor 2C, plays a pivotal role in neurotransmission and neuromodulation. This G-protein coupled receptor binds to serotonin, as well as various drugs and psychoactive substances, including LSD, initiating a cascade of signaling events. It modulates neuronal activity, influences appetite, stress responses, and regulates corticosterone release through its effect on calcium ion channels and phosphatidylinositol signaling pathways.
Therapeutic significance:
Understanding the role of 5-hydroxytryptamine receptor 2C could open doors to potential therapeutic strategies. Its involvement in regulating appetite, stress responses, and neuronal activity positions it as a key target for addressing disorders related to these functions.