Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P29322
UPID:
EPHA8_HUMAN
Alternative names:
EPH- and ELK-related kinase; EPH-like kinase 3; Tyrosine-protein kinase receptor EEK
Alternative UPACC:
P29322; Q6IN80; Q8IUX6; Q9NUA9; Q9P269
Background:
Ephrin type-A receptor 8, known as EPHA8, is a receptor tyrosine kinase involved in critical cellular processes. It binds with ephrin-A family ligands for bidirectional signaling, crucial for cell adhesion, migration, and nervous system development. EPHA8's interaction with EFNA5 influences integrin-mediated cell dynamics and neurite outgrowth, highlighting its role in axon guidance.
Therapeutic significance:
Understanding the role of Ephrin type-A receptor 8 could open doors to potential therapeutic strategies.