Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P31943
UPID:
HNRH1_HUMAN
Alternative names:
-
Alternative UPACC:
P31943; B3KW86; D3DWQ2; Q6IBM4
Background:
Heterogeneous nuclear ribonucleoprotein H plays a pivotal role in the post-transcriptional modification of pre-mRNAs, influencing alternative splicing and the production of functional mRNAs. Its interaction with components like CUGBP1 modulates insulin receptor mRNA splicing, showcasing its regulatory capacity in gene expression.
Therapeutic significance:
The protein's involvement in neurodevelopmental disorder with craniofacial dysmorphism and skeletal defects highlights its potential as a target for therapeutic intervention. Understanding the role of Heterogeneous nuclear ribonucleoprotein H could open doors to potential therapeutic strategies.