Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
It includes extensive molecular simulations of the receptor in its native membrane environment and the ensemble virtual screening accounting for its conformational mobility. In the case of dimeric or oligomeric receptors, the whole functional complex is modelled, and the tentative binding pockets are determined on and between the subunits to cover the whole spectrum of possible mechanisms of action.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P32249
UPID:
GP183_HUMAN
Alternative names:
Epstein-Barr virus-induced G-protein coupled receptor 2
Alternative UPACC:
P32249; B2R8N5; Q53F99; Q5JUH7
Background:
G-protein coupled receptor 183 (GPR183), also known as Epstein-Barr virus-induced G-protein coupled receptor 2, plays a pivotal role in immune system regulation. It acts as a chemotactic receptor for various cells including B-cells, T-cells, and astrocytes, mediated by its interaction with oxysterols such as 7-alpha,25-dihydroxycholesterol. GPR183 is crucial for the localization and movement of immune cells, facilitating proper immune responses and cell communication.
Therapeutic significance:
Understanding the role of G-protein coupled receptor 183 could open doors to potential therapeutic strategies. Its involvement in guiding immune cell migration and differentiation highlights its potential as a target for modulating immune responses in various diseases.