Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P35637
UPID:
FUS_HUMAN
Alternative names:
75 kDa DNA-pairing protein; Oncogene FUS; Oncogene TLS; POMp75; Translocated in liposarcoma protein
Alternative UPACC:
P35637; Q9H4A8
Background:
The RNA-binding protein FUS, also known as Translocated in liposarcoma protein and Oncogene FUS, plays a pivotal role in transcription regulation, RNA splicing, transport, and DNA repair. It is essential for cellular processes including dendritic spine formation and synaptic homeostasis, highlighting its importance in neuronal cell function.
Therapeutic significance:
FUS is implicated in diseases such as Angiomatoid fibrous histiocytoma, Amyotrophic lateral sclerosis 6, and Hereditary essential tremor 4. Its involvement in these conditions underscores the potential of targeting FUS for therapeutic strategies, offering hope for treatments.