Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P37198
UPID:
NUP62_HUMAN
Alternative names:
62 kDa nucleoporin; Nucleoporin Nup62
Alternative UPACC:
P37198; B3KWU5; Q503A4; Q6GTM2; Q96C43; Q9NSL1
Background:
Nuclear pore glycoprotein p62, also known as Nucleoporin Nup62, is a pivotal component of the nuclear pore complex. It plays a crucial role in nucleocytoplasmic transport, protein-protein interactions, and mitotic cell cycle progression. Its involvement in centrosome segregation, centriole maturation, and spindle orientation underscores its significance in cellular division and integrity.
Therapeutic significance:
The association of Nucleoporin Nup62 with Infantile striatonigral degeneration, a neurological disorder, highlights its potential as a therapeutic target. Understanding the role of Nuclear pore glycoprotein p62 could open doors to potential therapeutic strategies for this debilitating condition.