Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
This includes comprehensive molecular simulations of the receptor in its native membrane environment, paired with ensemble virtual screening that factors in its conformational mobility. In cases involving dimeric or oligomeric receptors, the entire functional complex is modelled, pinpointing potential binding pockets on and between the subunits to capture the full range of mechanisms of action.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P41594
UPID:
GRM5_HUMAN
Alternative names:
-
Alternative UPACC:
P41594; Q6J164
Background:
Metabotropic glutamate receptor 5 (mGluR5) is a G-protein coupled receptor that plays a pivotal role in synaptic plasticity and neural network activity. It functions by binding glutamate, which triggers a conformational change leading to signaling through G proteins. This signaling pathway activates a phosphatidylinositol-calcium second messenger system, resulting in a calcium-activated chloride current.
Therapeutic significance:
Understanding the role of Metabotropic glutamate receptor 5 could open doors to potential therapeutic strategies.