Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P42285
UPID:
MTREX_HUMAN
Alternative names:
ATP-dependent RNA helicase DOB1; ATP-dependent RNA helicase SKIV2L2; Superkiller viralicidic activity 2-like 2; TRAMP-like complex helicase
Alternative UPACC:
P42285; Q2M386; Q6MZZ8; Q6P170; Q8N5R0; Q8TAG2
Background:
Exosome RNA helicase MTR4, also known as ATP-dependent RNA helicase DOB1, plays a pivotal role in RNA metabolism. It catalyzes the ATP-dependent unwinding of RNA duplexes, essential for the degradation of RNA in eukaryotic nuclei. MTR4 is a central subunit in several protein complexes, including TRAMP-like, NEXT, and PAXT, which are crucial for the surveillance and turnover of aberrant transcripts and non-coding RNAs.
Therapeutic significance:
Understanding the role of Exosome RNA helicase MTR4 could open doors to potential therapeutic strategies.