Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P43146
UPID:
DCC_HUMAN
Alternative names:
Colorectal cancer suppressor; Immunoglobulin superfamily DCC subclass member 1; Tumor suppressor protein DCC
Alternative UPACC:
P43146
Background:
The Netrin receptor DCC, also known as Colorectal cancer suppressor and Tumor suppressor protein DCC, plays a pivotal role in axon guidance. It functions as a receptor for netrin, mediating axon attraction in the developing nervous system and is essential for neuronal growth cone guidance. Additionally, DCC acts as a dependence receptor, initiating apoptosis in the absence of its ligand, netrin, highlighting its complex role in cellular signaling.
Therapeutic significance:
DCC's involvement in Mirror movements 1 and Gaze palsy with progressive scoliosis underscores its clinical relevance. These disorders, linked to genetic variants affecting DCC, manifest in neurological and developmental challenges. Understanding DCC's role could unveil new therapeutic strategies, particularly in neurodevelopmental disorders and cancer suppression, given its tumor suppressor function.