Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P45983
UPID:
MK08_HUMAN
Alternative names:
JNK-46; Stress-activated protein kinase 1c; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1
Alternative UPACC:
P45983; B5BTZ5; B7ZLV4; D3DX88; D3DX92; Q15709; Q15712; Q15713; Q308M2
Background:
Mitogen-activated protein kinase 8 (MAPK8), also known as c-Jun N-terminal kinase 1 (JNK1), plays a pivotal role in cell processes including proliferation, differentiation, and apoptosis. It is activated by various stimuli, leading to the phosphorylation of numerous transcription factors and regulatory proteins. JNK1's involvement in the SAP/JNK signaling pathway and its impact on transcriptional activity highlight its significance in cellular responses to stress.
Therapeutic significance:
Understanding the role of Mitogen-activated protein kinase 8 could open doors to potential therapeutic strategies. Its critical function in cell survival, apoptosis, and response to stress makes it a compelling target for drug discovery efforts aimed at treating diseases with underlying cellular dysregulation.