Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P49642
UPID:
PRI1_HUMAN
Alternative names:
DNA primase 49 kDa subunit
Alternative UPACC:
P49642
Background:
The DNA primase small subunit, also known as the 49 kDa subunit, plays a pivotal role in DNA replication. It is a crucial component of the DNA polymerase alpha complex, essential for the initiation of DNA synthesis. This protein is involved in synthesizing short RNA primers necessary for DNA polymerase to begin replication, highlighting its fundamental role in cellular division and genetic fidelity.
Therapeutic significance:
Primordial dwarfism-immunodeficiency-lipodystrophy syndrome, a disease linked to mutations affecting this protein, underscores its critical role in human health. Understanding the DNA primase small subunit's function could pave the way for innovative treatments for this and potentially other related genetic disorders.