Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P49643
UPID:
PRI2_HUMAN
Alternative names:
DNA primase 58 kDa subunit
Alternative UPACC:
P49643; Q53FJ8; Q6P1Q7; Q8WVL2; Q9H413
Background:
The DNA primase large subunit, also known as the 58 kDa subunit, is a crucial component of the DNA polymerase alpha complex. This complex is essential for the initiation of DNA synthesis, playing a pivotal role during the S phase of the cell cycle. It is involved in the formation of RNA primers necessary for DNA replication, working closely with other subunits within the complex to ensure accurate DNA synthesis across both leading and lagging strands.
Therapeutic significance:
Understanding the role of DNA primase large subunit could open doors to potential therapeutic strategies.