Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P49902
UPID:
5NTC_HUMAN
Alternative names:
Cytosolic 5'-nucleotidase II; Cytosolic IMP/GMP-specific 5'-nucleotidase; Cytosolic nucleoside phosphotransferase 5'N; High Km 5'-nucleotidase
Alternative UPACC:
P49902; B7Z382; D3DR91; Q5JUV5
Background:
Cytosolic purine 5'-nucleotidase, also known as Cytosolic 5'-nucleotidase II, plays a pivotal role in cellular metabolism by regulating purine nucleoside/nucleotide pools. This enzyme exhibits broad specificity, catalyzing the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates and transferring phosphates between nucleoside monophosphates, with a preference for inosine, deoxyinosine, and guanosine.
Therapeutic significance:
Linked to Spastic paraplegia 45, autosomal recessive, a neurodegenerative disorder, understanding the role of Cytosolic purine 5'-nucleotidase could open doors to potential therapeutic strategies, especially considering its involvement in regulating critical purine levels in the cell.