Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P51610
UPID:
HCFC1_HUMAN
Alternative names:
C1 factor; CFF; VCAF; VP16 accessory protein
Alternative UPACC:
P51610; Q6P4G5
Background:
Host cell factor 1 (HCFC1), also known as C1 factor or VCAF, plays a pivotal role in cell cycle control, transcriptional regulation, and chromatin modification. It acts as a transcriptional coregulator, influencing the expression of genes critical for cell proliferation and development. HCFC1's interaction with various proteins, including EGR2, GABP2, and the Set1/Ash2 and Sin3 complexes, underscores its versatile role in gene expression. Additionally, it is involved in the cellular response to human herpes simplex virus infection by forming a complex that activates viral gene transcription.
Therapeutic significance:
HCFC1's involvement in methylmalonic aciduria and homocystinuria, cblX type, a metabolic disorder with severe neurological manifestations, highlights its potential as a therapeutic target. Understanding the role of HCFC1 could open doors to potential therapeutic strategies.