Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P52732
UPID:
KIF11_HUMAN
Alternative names:
Kinesin-like protein 1; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; Thyroid receptor-interacting protein 5
Alternative UPACC:
P52732; A0AV49; B2RMV3; Q15716; Q5VWX0
Background:
Kinesin-like protein KIF11, also known as Kinesin-like spindle protein HKSP, plays a pivotal role in cell division by establishing a bipolar spindle during mitosis. Beyond its critical function in mitosis, KIF11 is essential for the transport of secretory proteins from the Golgi complex to the cell surface in non-mitotic cells, showcasing its versatility in cellular operations.
Therapeutic significance:
KIF11's involvement in Microcephaly with or without chorioretinopathy, lymphedema, or impaired intellectual development highlights its potential as a therapeutic target. Understanding the role of Kinesin-like protein KIF11 could open doors to potential therapeutic strategies for treating this complex disorder.