Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P52746
UPID:
ZN142_HUMAN
Alternative names:
-
Alternative UPACC:
P52746; Q92510
Background:
Zinc finger protein 142 plays a crucial role in the cellular machinery, potentially influencing transcriptional regulation. Its unique structure, characterized by zinc finger motifs, suggests a specific interaction with DNA, guiding gene expression patterns critical for cellular function and development.
Therapeutic significance:
Linked to a neurodevelopmental disorder characterized by impaired speech and hyperkinetic movements, Zinc finger protein 142's dysfunction underscores its importance in neurological development and function. Understanding the role of Zinc finger protein 142 could open doors to potential therapeutic strategies for managing and treating this disorder.