Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P54317
UPID:
LIPR2_HUMAN
Alternative names:
Cytotoxic T lymphocyte lipase; Galactolipase; Triacylglycerol lipase
Alternative UPACC:
P54317; A0A075B781; A8K627; Q6IB55
Background:
Pancreatic lipase-related protein 2, also known as Cytotoxic T lymphocyte lipase, Galactolipase, and Triacylglycerol lipase, plays a pivotal role in lipid metabolism. It hydrolyzes triglycerides and galactosylglycerides, crucial for dietary fat digestion, especially in neonates. This protein is adept at breaking down fats of varying chain lengths and is essential for the absorption of long-chain polyunsaturated fatty acids from a plant-based diet. Its activity shifts from triglyceride hydrolysis to galactolipase and monoacylglycerol lipase as the liver matures.
Therapeutic significance:
Understanding the role of Pancreatic lipase-related protein 2 could open doors to potential therapeutic strategies.