Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P54922
UPID:
ADPRH_HUMAN
Alternative names:
ADP-ribose-L-arginine cleaving enzyme; [Protein ADP-ribosylarginine] hydrolase
Alternative UPACC:
P54922; B2R8H1; D3DN83
Background:
ADP-ribosylhydrolase ARH1, also known as ADP-ribose-L-arginine cleaving enzyme or [Protein ADP-ribosylarginine] hydrolase, plays a crucial role in cellular processes by specifically acting as an arginine mono-ADP-ribosylhydrolase. This enzyme is pivotal in mediating the removal of mono-ADP-ribose attached to arginine residues on proteins, a process essential for maintaining protein function and cellular homeostasis.
Therapeutic significance:
Understanding the role of ADP-ribosylhydrolase ARH1 could open doors to potential therapeutic strategies. Its unique enzymatic activity in protein regulation underscores its potential as a target for drug discovery, aiming to modulate protein functions in various diseases.