Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P55008
UPID:
AIF1_HUMAN
Alternative names:
Ionized calcium-binding adapter molecule 1; Protein G1
Alternative UPACC:
P55008; A8K406; O43904; Q9UIV4; Q9UKS9
Background:
Allograft inflammatory factor 1, also known as Ionized calcium-binding adapter molecule 1 and Protein G1, is a pivotal actin-binding protein. It plays a crucial role in enhancing membrane ruffling, RAC activation, and the actin-bundling activity of LCP1. Its ability to bind calcium underscores its importance in various cellular processes, including RAC signaling, phagocytosis, macrophage activation, vascular smooth muscle cell proliferation, T-lymphocyte proliferation, lymphocyte migration, and vascular inflammation.
Therapeutic significance:
Understanding the role of Allograft inflammatory factor 1 could open doors to potential therapeutic strategies. Its involvement in critical cellular processes and immune responses highlights its potential as a target for therapeutic intervention in diseases characterized by abnormal cell proliferation, immune dysfunction, and inflammation.