Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P55771
UPID:
PAX9_HUMAN
Alternative names:
-
Alternative UPACC:
P55771; Q99582; Q9UQR4
Background:
Paired box protein Pax-9 plays a crucial role in the development of various organs, including thymus, parathyroid glands, and teeth. It functions as a transcription factor, essential for the normal formation of skeletal elements of the skull, larynx, and distal limbs.
Therapeutic significance:
The protein's mutation is linked to Tooth agenesis, selective, 3, a condition characterized by the congenital absence of one or more teeth. Understanding the role of Paired box protein Pax-9 could open doors to potential therapeutic strategies for dental anomalies.