Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
It includes extensive molecular simulations of the receptor in its native membrane environment and the ensemble virtual screening accounting for its conformational mobility. In the case of dimeric or oligomeric receptors, the whole functional complex is modelled, and the tentative binding pockets are determined on and between the subunits to cover the whole spectrum of possible mechanisms of action.
Key features that set our library apart include:
partner
Reaxense
upacc
P56373
UPID:
P2RX3_HUMAN
Alternative names:
ATP receptor; Purinergic receptor
Alternative UPACC:
P56373; Q6DK37; Q9UQB6
Background:
P2X purinoceptor 3, also known as ATP receptor or Purinergic receptor, is a key player in the body's sensory system. Acting as a ligand-gated cation channel, it facilitates the flow of ions across the cell membrane in response to ATP binding. This protein is essential for the normal perception of pain and taste, highlighting its critical role in sensory experiences.
Therapeutic significance:
Understanding the role of P2X purinoceptor 3 could open doors to potential therapeutic strategies. Its pivotal function in pain perception makes it a promising target for developing novel pain management therapies, offering hope for individuals suffering from chronic pain conditions.