Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P56470
UPID:
LEG4_HUMAN
Alternative names:
Antigen NY-CO-27; L-36 lactose-binding protein; Lactose-binding lectin 4
Alternative UPACC:
P56470
Background:
Galectin-4, known by alternative names such as Antigen NY-CO-27, L-36 lactose-binding protein, and Lactose-binding lectin 4, plays a crucial role in cellular processes. It is a galectin that binds lactose and a related range of sugars, indicating its involvement in carbohydrate recognition processes. This protein is particularly noted for its potential role in the assembly of adherens junctions, which are essential for the maintenance of epithelial cell integrity and the regulation of cell-cell adhesion.
Therapeutic significance:
Understanding the role of Galectin-4 could open doors to potential therapeutic strategies. Its involvement in the assembly of adherens junctions suggests a fundamental role in cellular integrity and adhesion, processes often disrupted in various diseases. Exploring Galectin-4's functions further could lead to novel approaches in treating conditions where cell adhesion and integrity are compromised.