Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P59910
UPID:
DJB13_HUMAN
Alternative names:
Testis and spermatogenesis cell-related protein 6; Testis spermatocyte apoptosis-related gene 6 protein; Testis spermatogenesis apoptosis-related gene 3 protein; Testis spermatogenesis apoptosis-related gene 6 protein
Alternative UPACC:
P59910; B3LEP4; Q8IZW5
Background:
DnaJ homolog subfamily B member 13, known by alternative names such as Testis and spermatogenesis cell-related protein 6, plays a crucial role in the motility of sperm and cilia through its function in axonemal radial spoke complexes. This protein's involvement in the intricate processes of spermatogenesis and ciliary movement underscores its biological significance.
Therapeutic significance:
Linked to Ciliary dyskinesia, primary, 34, a disorder marked by motile cilia abnormalities leading to severe respiratory infections and bronchiectasis, DnaJ homolog subfamily B member 13 represents a promising target for therapeutic intervention. Understanding its role could open doors to potential therapeutic strategies.