Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P61619
UPID:
S61A1_HUMAN
Alternative names:
-
Alternative UPACC:
P61619; P38378; P57726; Q5JPF8; Q8N0Z4; Q8N3U3; Q8NC71; Q9BU16; Q9Y2R3
Background:
Protein transport protein Sec61 subunit alpha isoform 1 is a key component of the SEC61 channel-forming translocon complex, crucial for transporting precursor polypeptides across the endoplasmic reticulum. It plays a pivotal role in cotranslational translocation, ER membrane insertion of transmembrane proteins, and maintenance of cellular calcium homeostasis.
Therapeutic significance:
Given its involvement in Tubulointerstitial kidney disease, autosomal dominant, 5, understanding the role of Protein transport protein Sec61 subunit alpha isoform 1 could open doors to potential therapeutic strategies.