Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q00722
UPID:
PLCB2_HUMAN
Alternative names:
Phosphoinositide phospholipase C-beta-2; Phospholipase C-beta-2
Alternative UPACC:
Q00722; A8K6J2; B9EGH5
Background:
The 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2, also known as Phosphoinositide phospholipase C-beta-2 or Phospholipase C-beta-2, plays a pivotal role in cellular processes. It is instrumental in the production of second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), which are crucial for the transduction of extracellular signals.
Therapeutic significance:
Understanding the role of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 could open doors to potential therapeutic strategies. Its involvement in signal transduction pathways offers a promising avenue for the development of novel treatments.