Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q00987
UPID:
MDM2_HUMAN
Alternative names:
Double minute 2 protein; Oncoprotein Mdm2; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2
Alternative UPACC:
Q00987; A6NL51; A8K2S6; Q13226; Q13297; Q13298; Q13299; Q13300; Q13301; Q53XW0; Q71TW9; Q8WYJ1; Q8WYJ2; Q9UGI3; Q9UMT8
Background:
E3 ubiquitin-protein ligase Mdm2, also known as Oncoprotein Mdm2 or p53-binding protein Mdm2, plays a pivotal role in cell cycle regulation and apoptosis. It mediates the ubiquitination and degradation of p53/TP53, inhibiting its cell cycle arrest and apoptotic functions. Mdm2 also targets other proteins for ubiquitination, including ARRB1, RB1, and IGF1R, influencing various cellular processes from DNA damage response to mitochondrial apoptosis.
Therapeutic significance:
The involvement of Mdm2 in Lessel-Kubisch syndrome, characterized by premature aging and kidney failure, underscores its potential as a therapeutic target. Understanding the role of E3 ubiquitin-protein ligase Mdm2 could open doors to potential therapeutic strategies, especially in conditions where p53/TP53 regulation is disrupted.