Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q06190
UPID:
P2R3A_HUMAN
Alternative names:
PP2A subunit B isoform PR72/PR130; PP2A subunit B isoform R3 isoform; PP2A subunit B isoforms B''-PR72/PR130; PP2A subunit B isoforms B72/B130; Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B
Alternative UPACC:
Q06190; A8KAE7; B4DNU1; B7ZAE3; Q06189; Q9NPQ5
Background:
The Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha, known by alternative names such as PP2A subunit B isoform PR72/PR130, plays a crucial role in cellular function. It modulates substrate selectivity and catalytic activity, directing the localization of the catalytic enzyme to specific subcellular compartments.
Therapeutic significance:
Understanding the role of Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha could open doors to potential therapeutic strategies.