Focused On-demand Library for Sperm-associated antigen 1

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.

We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.

The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.

Our top-notch dedicated system is used to design specialised libraries.

Fig. 1. The sreening workflow of Receptor.AI

Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.

Key features that set our library apart include:

The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.

partner

Reaxense

upacc

Q07617

UPID:

SPAG1_HUMAN

Alternative names:

HSD-3.8; Infertility-related sperm protein Spag-1

Alternative UPACC:

Q07617; A6NP70; B3KQ58; G3XAM3; Q7Z5G1

Background:

Sperm-associated antigen 1, also known as HSD-3.8 or Infertility-related sperm protein Spag-1, plays a crucial role in the cytoplasmic assembly of ciliary dynein arms, suggesting its involvement in motility and fertilization processes. This protein's ability to bind GTP and exhibit GTPase activity further underscores its biological significance.

Therapeutic significance:

Given its association with Primary Ciliary Dyskinesia, particularly type 28, which leads to chronic respiratory infections and potentially Kartagener syndrome, understanding the role of Sperm-associated antigen 1 could unveil novel therapeutic strategies aimed at mitigating these ciliary motility disorders.