Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q13117
UPID:
DAZ2_HUMAN
Alternative names:
-
Alternative UPACC:
Q13117; Q2KHN6; Q96P41; Q9NR91
Background:
Deleted in azoospermia protein 2 (DAZ2) plays a pivotal role in male fertility, acting as an RNA-binding protein essential for spermatogenesis. It specifically binds to the 3'-UTR of mRNAs, regulating their translation and ensuring proper sperm development.
Therapeutic significance:
DAZ2 is directly linked to Spermatogenic failure Y-linked 2, a condition marked by reduced or absent sperm in semen, leading to male infertility. Understanding the role of DAZ2 could open doors to potential therapeutic strategies for treating male infertility.