Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q13415
UPID:
ORC1_HUMAN
Alternative names:
Replication control protein 1
Alternative UPACC:
Q13415; D3DQ34; Q13471; Q5T0F5
Background:
Origin recognition complex subunit 1 (ORC1) is a pivotal component of the origin recognition complex, crucial for the initiation of DNA replication. It binds to origins of replication in an ATP-dependent manner, although the specific DNA sequences recognized remain unidentified. This protein plays a key role in assembling the pre-replication complex necessary for DNA synthesis to commence.
Therapeutic significance:
ORC1's involvement in Meier-Gorlin syndrome 1, characterized by growth retardation and skeletal anomalies, underscores its potential as a therapeutic target. Understanding ORC1's function could lead to novel strategies for managing this syndrome.