Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q14119
UPID:
VEZF1_HUMAN
Alternative names:
Putative transcription factor DB1; Zinc finger protein 161
Alternative UPACC:
Q14119
Background:
Vascular endothelial zinc finger 1, also known as Putative transcription factor DB1 and Zinc finger protein 161, plays a crucial role in gene expression regulation. It specifically binds to the CT/GC-rich region of the interleukin-3 promoter, mediating tax transactivation of IL-3. This protein's involvement in transcriptional regulation underscores its importance in cellular functions and disease mechanisms.
Therapeutic significance:
Linked to Cardiomyopathy, dilated, 1OO, a condition characterized by ventricular dilation and impaired systolic function leading to congestive heart failure and arrhythmia, Vascular endothelial zinc finger 1's study offers insights into genetic underpinnings of heart diseases. Understanding its role could pave the way for novel therapeutic strategies targeting genetic variants affecting this protein.