Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q14141
UPID:
SEPT6_HUMAN
Alternative names:
-
Alternative UPACC:
Q14141; Q5JTK0; Q969W5; Q96A13; Q96GR1; Q96P86; Q96P87
Background:
Septin-6, a filament-forming cytoskeletal GTPase, plays a crucial role in the organization of the actin cytoskeleton and cytokinesis. It is essential for HCV RNA replication and forms a complex with SEPTIN12, SEPTIN6, SEPTIN2, and SEPTIN4, vital for sperm tail integrity and motility.
Therapeutic significance:
Understanding the role of Septin-6 could open doors to potential therapeutic strategies.