Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q14289
UPID:
FAK2_HUMAN
Alternative names:
Calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; Focal adhesion kinase 2; Proline-rich tyrosine kinase 2; Related adhesion focal tyrosine kinase
Alternative UPACC:
Q14289; D3DST0; Q13475; Q14290; Q16709; Q6PID4
Background:
Protein-tyrosine kinase 2-beta, also known as Calcium-dependent tyrosine kinase, plays a pivotal role in various cellular processes including actin cytoskeleton reorganization, cell migration, and immune response regulation. It is essential for normal B-cell migration in the spleen, macrophage polarization, and T-cell responses. Additionally, it contributes to bone remodeling by promoting osteoclastic bone resorption and may inhibit osteoprogenitor cell differentiation.
Therapeutic significance:
Understanding the role of Protein-tyrosine kinase 2-beta could open doors to potential therapeutic strategies.