Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q14320
UPID:
FA50A_HUMAN
Alternative names:
Protein HXC-26; Protein XAP-5
Alternative UPACC:
Q14320; A8KAQ4; B2R997; Q5HY37; Q6PJH5
Background:
Protein FAM50A, also known as Protein HXC-26 and Protein XAP-5, plays a crucial role in the regulation of pre-mRNA splicing. This process is fundamental for the correct expression of genes, impacting cellular function and organism development.
Therapeutic significance:
Linked to Intellectual developmental disorder, X-linked, syndromic, Armfield type, FAM50A's dysfunction showcases the protein's critical role in neurological development. Understanding the role of Protein FAM50A could open doors to potential therapeutic strategies for this disorder.