Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q14397
UPID:
GCKR_HUMAN
Alternative names:
-
Alternative UPACC:
Q14397; A1L4C2; B4DPQ2; Q53RY6; Q99522
Background:
The Glucokinase regulatory protein plays a pivotal role in glucose metabolism by regulating the activity of glucokinase (GCK), a key enzyme in the glycolytic pathway. It forms an inactive complex with GCK, modulating its activity in response to fructose metabolites. This regulation ensures a balanced glucose level in the body, highlighting the protein's critical function in energy homeostasis.
Therapeutic significance:
Understanding the role of Glucokinase regulatory protein could open doors to potential therapeutic strategies. Its central role in glucose metabolism makes it a promising target for the development of treatments for metabolic disorders, offering a pathway to innovative healthcare solutions.