Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q14651
UPID:
PLSI_HUMAN
Alternative names:
Intestine-specific plastin
Alternative UPACC:
Q14651; A8K2Q1; D3DNG3; Q8NEG6
Background:
Plastin-1, also known as Intestine-specific plastin, plays a pivotal role in the inner ear by bundling actin filaments. This process is crucial for the formation of stereocilia, which are essential for hearing. The protein's ability to mediate liquid packing of actin filaments ensures stereocilia reach their proper dimensions, highlighting its significance in auditory function.
Therapeutic significance:
Given its critical role in stereocilia formation, Plastin-1 is directly linked to Deafness, autosomal dominant, 76, a condition characterized by sensorineural hearing loss. Understanding the role of Plastin-1 could open doors to potential therapeutic strategies for treating hearing loss and preventing its progression.