Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q15286
UPID:
RAB35_HUMAN
Alternative names:
GTP-binding protein RAY; Ras-related protein Rab-1C
Alternative UPACC:
Q15286; B2R6E0; B4E390
Background:
Ras-related protein Rab-35, also known as GTP-binding protein RAY and Ras-related protein Rab-1C, plays a pivotal role in intracellular membrane trafficking. It regulates the transition between the inactive GDP-bound form and the active GTP-bound form, facilitating vesicle formation, movement, tethering, and fusion. Rab-35 is crucial for endocytosis, cytokinesis, and the fast recycling pathway, impacting cellular processes such as intercellular bridge stability and insulin-induced glucose transporter translocation in adipocytes.
Therapeutic significance:
Understanding the role of Ras-related protein Rab-35 could open doors to potential therapeutic strategies.