Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q15375
UPID:
EPHA7_HUMAN
Alternative names:
EPH homology kinase 3; EPH-like kinase 11
Alternative UPACC:
Q15375; A0AUX7; B2R8W1; B7ZLJ9; B7ZLK0; Q59G40; Q5VTU0; Q8N368; Q9H124
Background:
Ephrin type-A receptor 7, also known as EPH homology kinase 3 or EPH-like kinase 11, is a pivotal receptor tyrosine kinase. It engages in bidirectional signaling via GPI-anchored ephrin-A family ligands, crucial for brain development, axon guidance, and topographic mapping of retinal axons. Its interaction with EFNA5 modulates cell-cell adhesion and repulsion, influencing corticothalamic axons' guidance and the colliculus's mapping.
Therapeutic significance:
Understanding the role of Ephrin type-A receptor 7 could open doors to potential therapeutic strategies.