Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q15468
UPID:
STIL_HUMAN
Alternative names:
TAL-1-interrupting locus protein
Alternative UPACC:
Q15468; Q5T0C5; Q68CN9
Background:
The SCL-interrupting locus protein, also known as TAL-1-interrupting locus protein, plays a pivotal role in embryonic development, cellular growth, and proliferation. It is a key regulator of the sonic hedgehog pathway and is essential for centriole duplication and proper mitotic progression. Its activity influences cell survival and the cell cycle, highlighting its importance in cellular function.
Therapeutic significance:
Linked to Microcephaly 7, primary, autosomal recessive, a condition characterized by significantly reduced brain size and mental retardation, the SCL-interrupting locus protein's genetic variants underscore its critical role in brain development. Understanding the role of this protein could open doors to potential therapeutic strategies for treating microcephaly and related neurological disorders.