Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q15661
UPID:
TRYB1_HUMAN
Alternative names:
Tryptase I; Tryptase alpha-1
Alternative UPACC:
Q15661; D2E6R9; D2E6S1; P15157; Q15663; Q6B052; Q9H2Y4; Q9H2Y5; Q9UQI1
Background:
Tryptase alpha/beta-1, also known as Tryptase I or Tryptase alpha-1, is the principal neutral protease in mast cells, released during the activation-degranulation response. This enzyme plays a pivotal role in innate immunity, with isoform 2 showing higher efficiency in cleaving large substrates like fibronectin compared to isoform 1, albeit with reduced efficacy on smaller substrates.
Therapeutic significance:
Understanding the role of Tryptase alpha/beta-1 could open doors to potential therapeutic strategies. Its involvement in mast cell activation suggests a key position in allergic reactions and other immune responses, making it a compelling target for drug discovery efforts aimed at modulating immune system disorders.